Jr Research Scientist - Protein Production Scientific Departments
IRBM S.p.A.
Roma
20
Scarso
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Azienda: IRBM S.p.A. Roma
Esperienza: Esperienza con purificazione proteine
Titolo di studio: Laurea in Biologia o Chimica
NMR Unit
IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.
With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.
Job Description
We are looking for a passionate and talented scientist whohas an interestin structural biology and structure-based drug discovery.The successful candidate will work in a highly collaborative research environment and willbe in charge ofproducing high-quality protein samples for structural biology projects and biophysical applications. The applicant must have solid training in protein biochemistry, protein overexpression in bacterial/eukaryotic systems and experience in protein purification. The new resource will work closely with the NMR group and will assist in sample preparation for spectroscopic studies. Additionally, the successful candidatewill be responsible forpreparing protein standards for method development and biological reagents for biological assays and screenings.
Key responsibilities
Apply, optimize, and innovate protein purification processes. Maximize protein yields, activity, stability and purity
Execute and troubleshoot bench experiments carefully and precisely. Apply standard molecular biology, biochemical and cell biology techniques to achieve research goals
Sustain protein production for internal and external projects
Perform ongoing care and upkeep of instruments used primarily for protein production
Provide support to the NMR group and participate to research activities aimed at improving existing and/or developing new tools for structural biology
Perform technical evaluation of research experiments and results, perform data analysis and keep detailed records of data
Present data and reports on project status to multidisciplinary teams and external collaborators
Experience with expression and purification of recombinant proteins from coli and mammalian cultures
Hands on experience in various chromatographic purification techniques, including but not limited to affinity, ion exchange, and size exclusion
Knowledge of cloning techniques for plasmid construction
Hands on experience in insect cell-based protein expression is not essential but will be considered a plus
Extremely organized and able to efficiently manage time and operations considering both long-term projects and day-to-day responsibilities
Highly collaborative, team-oriented, and able to learn quickly
Outstanding oral and written communication skills, particularly when collaborating with other teams with limited knowledge of your area of expertise
Excellent knowledge of spoken and written English is mandatory
Qualifications
Required: Ph.D. in Biological Sciences (Structural Biology, Biochemistry, or related fields) or equivalent experience in an industrial setting
During the job interview we will evaluate candidates’ experience and the job offer will be commensurate.
We thank all applicants for their interest, candidates selected for interviews will be contacted.
IRBM considers all qualified applicants without discrimination, including on the basis of race, gender, age, disability, gender identity or expression, national origin, religion, sexual orientation, or other protected classes. We nurture an inclusive culture where everyone can show their full potential and enjoy a fulfilling career.
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✔ IRBM S.p.A.